Search. In addition, oral Bifidobacterium longum is also an effective treatment of ethanol-induced gastritis injury. 6, p. 1581, 2020. 506519, 2019. Contains a unique patented combination of inactivated Bifidobacterium longum CBi0703 and Vitamin C, specifically formulated to support the joints*, Once daily capsule, taken with or without food, Excellent safety profileNo known side effects or drug interactions. T. Zhang, J. Jiang, J. Liu et al., MK2 is required for neutrophil-derived ROS production and inflammatory bowel disease, Frontiers in Medicine, vol. This is a randomized, double-blind, placebo-controlled, parallel group study, designed to assess the effectiveness & safety of Bifidobacterium longum 1714 strain in people with low mood. Bookshelf C16:0 and C18:0 fatty acids detected in the aggregates further supported a lipoprotein structure. What happens in a joint with osteoarthritis? Bifidobacterium longum belongs to the genera Actinomyces and Bifidobacterium. Amount Per Serving. 2016 Sep;(5):80-87. 42554265, 2018. Castlebar, Recently, studies have found that Bifidobacterium longum can be used as an adjuvant treatment for IBD [10]. L.-M. Weber, A. Fischer, S. Scholz, D. Metzke, and D. C. Baumgart, Impact of proinflammatory cytokines and mesalamine on the expression of the tight junction protein claudin-1 in intestinal epithelial cells, Gastroenterology, vol. Glucose and mannose detected by gas chromatography were likely ligands of the lipoprotein. 5259, 2018. This harmonious and stable symbiotic relationship can regulate mucosal immunity and prevent the colonization of pathogens in the intestine [94] (Figure 1). B. Nascimento, M. E. R. Andrade et al., Treatment withBifidobacterium longum51A attenuates intestinal damage and inflammatory response in experimental colitis, Beneficial Microbes, vol. The aim of this study was to evaluate the effects of a lyophilized inactivated culture (LIC) from Bifidobacterium longum CBi0703 in a spontaneous model of 2, no. 8, pp. The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network. The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user. 12, no. Amino Acids. Therefore, the results of clinical trials prove that the use of Bifidobacterium longum alone or in combination with other probiotics can effectively improve the symptoms of IBD patients. 149, article 104585, 2020. W. G. Kim, H. I. Kim, E. K. Kwon, M. J. Han, and D. H. Kim, Lactobacillus plantarumLC27 andBifidobacterium longumLC67 mitigate alcoholic steatosis in mice by inhibiting LPS-mediated NF-B activation through restoration of the disturbed gut microbiota, Food & Function, vol. WebThe mechanisms underlying acid response and adaptation in Bifidobacterium longum biotype longum NCIMB 8809 and its acid-pH-resistant mutant B. longum biotype longum 8809dpH were studied. 1, pp. F. Zuo, R. Yu, M. Xiao et al., Transcriptomic analysis of Bifidobacterium longum subsp. Feeding mice with Bifidobacterium longum strains Bif10 and Bif16 could reduce their crypt deformation, diarrhea, etc. 568571, 2014. 29, no. A. M. Ehrlich, A. R. Pacheco, B. M. Henrick et al., Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells, BMC Microbiology, vol. Z. W. Liu, Z. P. Ren, J. Zhang et al., Role of ROS and nutritional antioxidants in human diseases, Frontiers in Physiology, vol. 12, no. Unable to load your collection due to an error, Unable to load your delegates due to an error. 7, pp. In this review, we will focus on the cell and animal experiments and clinical trials to summarize the mechanisms of Bifidobacterium longum on the prevention and treatment of IBD, which would provide a basis for subsequent therapeutic applications. S. V. Rana, S. Sharma, K. K. Prasad, S. K. Sinha, and K. Singh, Role of oxidative stress & antioxidant defence in ulcerative colitis patients from North India, Indian Journal of Medical Research, vol. They belong to the Bifidobacteriaceae family and are characterized by high genomic G+C content (5567 mol%) [ 1 ]. 2, pp. 389398, 2017. 1, pp. 1, pp. Cell wall lipoprotein aggregates (LpAs) secreted by the selected strains were assayed for their antiviral activity. A large number of animal experiments and clinical studies have shown that Bifidobacterium longum can reduce the symptoms of colitis and relieve chronic inflammation [16]. This low-grade inflammation appears to be related to the composition of the gut microbiota. WebBifidobacterium longum subsp. 1, 2020. S. Fourie, D. Jackson, and H. Aveyard, Living with Inflammatory Bowel Disease: A review of qualitative research studies, International Journal of Nursing Studies, vol. In gnotobiotic mice, the intake of B. longum aggregate induced, in splenic dendritic cells, the expression of genes involved in antigen presentation. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. 2, pp. B. Chami, N. J. J. Martin, J. M. Dennis, and P. K. Witting, Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease, Archives of Biochemistry and Biophysics, vol. 10, no. 14, article 100294, 2021. 297302, 2020. WebObjective: The aim of this study was to evaluate the effects of a lyophilized inactivated culture (LIC) from Bifidobacterium longum CBi0703 in a spontaneous model of osteoarthritis (OA) 7, 2016. For example, when it was used together with the prebiotic synergy 1, the CD activity and histological score were reduced [104]. Under normal circumstances, the mucosal cells of the intestine can keep the proinflammatory and anti-inflammatory cytokines in a relatively balanced state [51]. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Dysbiosis: Adverse alterations in the diversity, structure or function of gut microbiota that is associated with disease, Bifidobacterium longum CBi0703 has been fully characterised and selected for use in osteoarthritis based on its immunomodulatory properties 13 14, 320 male and females with mild-moderate osteoarthritis, 1 capsule/day (Bifidobacterium longum CBi0703 + Vitamin C), Pamex LimitedMoneen Business ParkCastlebarCo. Cartilage is a firm, slippery tissue than cushions the ends of bones and enables smooth joint movement. In IBD, the intestinal permeability of the patients intestinal mucosa increases, and the expression of the tight junction protein (TJP) decreases, which affects the protective function of the intestine and causes inflammation [87]. 0 . 2, pp. R. Y. Gao, X. H. Zhang, L. S. Huang, R. R. Shen, and H. L. Qin, Gut microbiota alteration after long-term consumption of probiotics in the elderly, Probiotics and Antimicrobial Proteins, vol. Treg cells can express the transcription factor forkhead box P3 (FOXP3) and secrete the anti-inflammatory cytokine IL-10, thereby inhibiting a strong inflammatory response [55]. 18231836, 2017. In vitro experiments and animal models indicate that Bifidobacterium longum has anti-inflammatory effects on intestinal diseases (Table 1 and Table 2). E. Thursby and N. Juge, Introduction to the human gut microbiota, Biochemical Journal, vol. WebOverview Bifidobacterium longum (B. longum) is a type of probiotic ("good" bacteria) that lives in the intestines. Its main symptoms include diarrhea, abdominal cramps, weight loss, fatigue, anemia, and extraintestinal symptoms (especially joint pain or arthritis). Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. infantis ATCC 15697 = JCM 1222 = DSM 20088 G. Pizzino, N. Irrera, M. Cucinotta et al., Oxidative stress: harms and benefits for human health, Oxidative Medicine and Cellular Longevity, vol. 38, 2020. J. L. Zhao, X. J. Cai, W. Gao et al., Prussian blue nanozyme with multienzyme activity reduces colitis in mice, ACS Applied Materials & Interfaces, vol. WebBifidobacterium longum yang kebal antibiotik dapat membantu mengobati penyakit radiasi. 928935.e2, 2015. 32, no. Sun, J. Liu, J. Kan, and C. H. Jin, The impacts of natural polysaccharides on intestinal microbiota and immune responses - a review, Food & Function, vol. This study was supported by the Fundamental Research Funds for the Central Universities (Project No. 3, pp. As a pleiotropic cytokine, IL-6 plays a central role in immunoregulation, inflammation response, and oncogenesis. 83, pp. T. Liu, L. Zhang, D. Joo, and S.-C. Sun, NF-B signaling in inflammation, Signal Transduction and Targeted Therapy, vol. B. Xiao, and Y. L. Hao, A novel major pilin subunit protein FimM is involved in adhesion of Bifidobacterium longum BBMN68 to intestinal epithelial cells, Frontiers in Microbiology, vol. Additional test tubes can be inoculated by transferring 0. In contrast, no effect was shown by incubating HEp-2 cells with bifidobacteria prior to CV-B4 inoculation. Q. Guo, S. Li, Y. Xie et al., The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (H) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively, Free Radical Biology and Medicine, vol. In addition, it could significantly attenuate lipopolysaccharide- (LPS-) induced activation of NF-B in macrophages and significantly attenuate TNF-alpha and IL-8 in intestinal epithelial cells to protects gut epithelial cells [82, 83]. 15391546, 2005. Careers. T. Ma, H. Jin, L.-Y. 1957;16:494-502. We also use third-party cookies that help us analyze and understand how you use this website. M. Toscano, R. De Grandi, L. Stronati, E. De Vecchi, and L. Drago, Effect ofLactobacillus rhamnosusHN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: a preliminary study, World Journal of Gastroenterology, vol. Under pathogen invasion, FimM could competitively inhibit pathogen adhesion by binding to fibronectin and fibrinogen [98]. 23, no. 2610826117, 2018. K. Wang, Z. Wan, A. Ou et al., Monofloral honey from a medical plant,Prunella Vulgaris, protected against dextran sulfate sodium-induced ulcerative colitisviamodulating gut microbial populations in rats, Food & Function, vol. 24, no. Arthritis Research UK (2013) Osteoarthritis in general practice. LpA sequences form hydrogen bonds with viral residues involved in CAR binding. WebAnother recent study in a guinea pig model of spontaneous osteoarthritis showed that the oral administration of a lyophilized inactivated culture of Bifidobacterium longum CBi0703 10, no. 3, p. 126, 2019. 38, pp. For IBD patients, oxidative stress occurs with the raise of ROS levels and decline of antioxidant levels, which leads to chronic tissue damage continuously [38, 39] (Figure 1). 0 . To provide the best experiences, we use technologies like cookies to store and/or access device information. 100, no. (c) Bifidobacterium longum can produce various metabolites to enhance adhesion to the intestinal tract and inhibit harmful bacteria. M. Kitade, Y. Ogura, I. Monno, and D. Koya, Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function, Frontiers in Endocrinology, vol. 2 active sites 1 reviewed publication. M. F. Neurath, C. Becker, and K. Barbulescu, Role of NF-B in immune and inflammatory responses in the gut, Gut, vol. W. S. Song, H. G. Park, S. M. Kim et al., Chemical derivatization-based LC-MS/MS method for quantitation of gut microbial short-chain fatty acids, Journal of Industrial and Engineering Chemistry, vol. E. K. Kwon, G. D. Kang, W. K. Kim, M. J. Han, and D. H. Kim, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate ethanol-induced gastritis and hepatic injury in mice, Journal of Functional Foods, vol. Binding to fibronectin and fibrinogen [ 98 ], M. Xiao et al., Transcriptomic analysis of longum! Tubes can be used as an adjuvant treatment for IBD [ 10 ] Central Universities Project!, M. Xiao et al., Transcriptomic analysis of Bifidobacterium longum belongs to the family... Us to process data such as browsing behavior or unique IDs on bifidobacterium longum cbi0703 site of. Secreted by the Fundamental Research Funds for the Central Universities ( Project No invasion. Load your delegates due to an error storing preferences that are not by! 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