Biophys J. Still, in contrast to the abundant literature on NME1, only few data are available on NME4 expression in human cancers. Lee J, Roberts JS, Atanasova KR, Chowdhury N, Yilmaz . CL is synthesized in the inner mitochondrial membrane, leading to high CL concentrations in this membrane, while the CL content of the outer membrane is normally very low [52, 53]. Zhao J, Zhang J, Yu M, et al. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. Zhang F, Huang LY, Zhang F, Ali J, Cruz CV, Zhuo DL, Du ZL, Li ZK, Zhou YL. Epub 2018 Nov 17. J Cell Sci. With these various functions in cell homeostasis, NDPK-D/NME4 adds to the group of so-called moonlighting (or gene sharing) proteins. volume251, Articlenumber:77 (2020) Krebs HA, Wiggins D. Phosphorylation of adenosine monophosphate in the mitochondrial matrix. NDPK are found in all cells, displaying not much specificity towards the types of nucleoside bases and are capable of accepting nucleotides and deoxyribonucleotides as substrates or donors. 2007;357:254351. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). MacVicar T, Langer T. OPA1 processing in cell death and disease - the long and short of it. In enzymology, a nucleotide diphosphokinase (EC 2.7.6.4) is an enzyme that catalyzes the chemical reaction. J Bioenerg Biomembr. However, outer membrane CL is selectively increased in mitochondria isolated from HeLa cells over-expressing the wild-type NDPK-D/NME4 but not the membrane binding-deficient mutant (R90D), while phosphatidylcholine distribution remains unchanged [35]. The .gov means its official. Qin QP, Meng T, Tan MX, Liu YC, Wang SL, Zou BQ, Liang H. Medchemcomm. sharing sensitive information, make sure youre on a federal 8600 Rockville Pike Mol Cell Biochem 329(1):315, Miao Y, Jiang L (2007) Transient expression of fluorescent fusion proteins in protoplasts of suspension cultured cells. Despite the bacterial origin of mitochondria, the unique bacterial NDPK/NME enzyme has none of the NME4 characteristics, including membrane binding. Skotheim RI, Autio R, Lind GE, et al. [3] Epub 2013 Sep 25. CAS Map-based cloning identified that the mutation occurred in the OsNDPK4 gene. -. Milon L, Rousseau-Merck MF, Munier A, et al. Nat Protoc 7(3):562578, Tsukagoshi H, Busch W, Benfey PN (2010) Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. BMC Evol Biol. (Figure modified from Schlattner et al. FASEB J. J Bioenerg Biomembr 2000;32:22736. During cAMP-mediated signal transduction, NDPK is responsible for phosphorylating GDP released from G proteins activated from receptor binding; once ATP donates a phosphate group via activity of NDPK, GTP is consecutively bound. -, Cancer Res. 2002;13:44955. Federal government websites often end in .gov or .mil. [19], There was a lot of debate on whether NM23 gene is responsible for suppressing or activating metastasis. FEBS Lett. PubMed Other names in common use include nucleotide pyrophosphokinase, ATP:nucleotide pyrophosphotransferase, ATP nucleotide 3'-pyrophosphokinase, and nucleotide 3'-pyrophosphokinase. Similar phospholipid transfer was found with mtCK, another homo-oligomeric kinase in the intermembrane space that can crosslink two membranes [50]. Detailed analysis revealed that the dysfunction of OsNDPK4 might reorchestrate energy homeostasis and hormone metabolism and signalling, resulting in repression of translation, DNA replication and cell cycle progression, and priming of biotic stress defense. The rice mutant Osndpk4 showed severe defects in root development from the early seedling stage. The general reaction via ping-pong mechanism is as follows: XDP + YTP XTP + YDP (X and Y each represent different nitrogenous base). This indicates that optimal functioning of the kinase requires binding to the inner membrane for channeling ADP to ANT (ADP/ATP translocator) and oxidative phosphorylation and vice versa mitochondrial ATP to the NDPK-D/NME4 hexamer [34]. The gene (ndk), mapped at 54.2 min on the E. coli chromosome, was cloned and sequenced. Would you like email updates of new search results? Nme2 gene is known to form a complex with the beta subunit of the heterotrimetric G protein in heart cells and regulates the contractility of heart. Jin Ye and Wona Ding contributed equally to this paper. NDPK-D/NME4 interaction with model membranes also leads to structural alterations of both, the lipid bilayer and the NDPK-D/NME4 hexamer [40]. 1999;76:25469. [15] In addition to signaling, NDPK is involved in controlling K+ channels, cell secretion, and cellular energy production. In Eukaryotic systems, the role of the NDK is to synthesize nucleoside triphosphates other than ATP. J Biol Chem. A mitochondrial switch promotes tumor metastasis. Cell Growth Differ. Disclaimer. MC159 protein from the molluscum contagiosum instead inhibits NF-kappa-B activation by interacting with the IkB kinase complex . The ndk gene appears to be in a monocistronic operon and, when cloned in a pUC vector, NDP kinase was overproduced at a level of approx. Our results demonstrate that OsNDPK4 plays important roles in energy homeostasis, development process, and defense responses in rice. 2015;10:e0139616. eCollection 2022. -, Mol Cell Biol. Knorpp C, Johansson M, Baird AM. Plant Physiol 157(1):305316, Nomura T, Yatsunami K, Honda A, Sugimoto Y, Fukui T, Zhang J, Yamamoto J, Ichikawa A (1992) The amino acid sequence of nucleoside diphosphate kinase i from spinach leaves, as deduced from the cDNA sequence. This is done via a high energy phosphohistidine intermediate. Some CL-binding of NDPK-D/NME4 seems to be also required for its interaction with OPA1 [47]. 376. official website and that any information you provide is encrypted This work was supported by the National Natural Science Foundation of China [Grant Numbers 31300246, 31371595], the Zhejiang Provincial Natural Science Foundation of China [Grant Numbers LY17C020002], the Natural Science Foundation of Ningbo [Grant Number 2019A610413] and K. C. Wong Magna Fund in Ningbo University. Planta 224(1):108124, Dorion S, Clendenning A, Rivoal J (2017) Engineering the expression level of cytosolic nucleoside diphosphate kinase in transgenic solanum tuberosum roots alters growth, respiration and carbon metabolism. Mutations in this gene have been identified in aggressive neuroblastomas. Since these functions would imply the presence of NDPK-D/NME4 in the cytosol [25], further studies on protein localization in Xenopus are required. [8] AMPK acts as the energy sensor and regulates ATP pathways by turning the generating pathways or not. Nucleoside diphosphate kinases (NDPKs) are an evolutionarily conserved family of important enzymes balancing the energy currency nucleoside triphosphates by catalyzing the transfer of their phosphate groups. Few studies reported NME4 expression during development and differentiation. UniProtKB reviewed (Swiss-Prot) Organism. Mol Microbiol. Keywords: This site needs JavaScript to work properly. The binding may be indirect by using the signaling complex.[20]. (p)ppGpp biosynthesis is a part of the purine metabolism pathway and coordinates a series of cellular activities in response to nutritional abundances. Unauthorized use of these marks is strictly prohibited. Other known mitochondrial NDPK proteins that possess a canonical mitochondrial targeting sequence are found in amoeba [8], plants [26], and green alga [27]. ndk UniRule annotation. 1 publication. The hexameric structure (PDB 1EHW, monomer backbones in different colors, transparent van der Waals surface in gray) indicating one representative NDP kinase active site (red, phosphotransfer function through phosphorylation of histidine 151) and one basic amino acid triad capable of binding anionic phospholipids, including cardiolipin (blue, phospholipid transfer function). PubMed Central 1978;174:297301. Read More Article FEBS Lett. The site is secure. J Exp Bot 65(10):26332643, Thimm O, Blsing O, Gibon Y, Nagel A, Meyer S, Krger P, Selbig J, Mller LA, Rhee SY, Stitt M (2004) MapMan: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes. Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of terminal phosphate between different nucleoside diphosphates (NDP) and triphosphates (NTP) in a reversible manner to produce nucleotide triphosphates. Xu ZY, Chen JS, Shu YQ. [13], There are at least four enzymatically active isoforms of NDPK in humans: NDPK-A, NDPK-B, NDPK-C and NDPK-D. All four isoforms have very similar structures and can combine in any form to become functional NDPK hexamers. 2009;91:77983. Olichon A, Elachouri G, Baricault L, Delettre C, Belenguer P, Lenaers G. OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis. Behind this apparently simple reaction is a multistep mechanism. Ye, J., Ding, W., Chen, Y. et al. 2010;5:e15506. . The https:// ensures that you are connecting to the 2000 Jun;32(3):227-36. doi: 10.1023/a:1005580828141. Name. doi: 10.1111/cmi.12825. Furthermore, NDPK is involved with the signal transduction processes and G protein-coupled receptor endocytosis as it transfers a phosphate group onto the G -subunits and convert GDP to GTP. Mutations in this gene have been identified in aggressive neuroblastomas. Annotation score. Most if not all studies on the role of NDPK-D/NME4 in pathology concern cancer, probably because the cytosolic homolog NDPK-A/NME1 is a well studied metastasis suppressor [59]. Cytosolic type I NDPK is involved in metabolism, growth, and stress responses in plants. Google Scholar. Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer. These findings emphasize the importance of proper localization NDPK-D/NME4 for its NDP kinase function. 1991 Jan 1;51(1):445-9 2008;25:1318. Via its phospholipid transfer function, NME4 in the intermembrane space facilitates CL transfer to the mitochondrial surface as a pro-mitophagic or pro-apoptotic trigger, and may participate in phospholipid biosynthetic pathways between ER and mitochondria. Troll H, Winckler T, Lascu I, et al. Human isoforms A and B of nm23/nucleoside diphosphate (NDP) kinase, functionally important in development and cancer, have been reported . and transmitted securely. Bethesda, MD 20894, Web Policies ISSN 0023-6837 (print), The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis, https://doi.org/10.1038/s41374-017-0004-5, Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit, Mitochondrial proteins: from biogenesis to functional networks, The cell biology of mitochondrial membrane dynamics, Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes, Mechanisms and regulation of protein synthesis in mitochondria, The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain, Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response, UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae, Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate, The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor, Widely targeted metabolomic analyses unveil the metabolic variations after stable knock-down of NME4 in esophageal squamous cell carcinoma cells, The nucleoside diphosphate kinase superfamily: state of the art, United States & Canadian Academy of Pathology Annual Meeting Abstracts. Status. In different human cell lines, endogenous and overexpressed NDPK-D/NME4 wild-type and mutant proteins are all localizing to mitochondria as found by imaging techniques and classical cell fractionation [13, 34, 35]. Google Scholar. This is a preview of subscription content, access via your institution. Nm23-H2 also has an activity that cleaves DNA site-specifically, involving a covalent protein-DNA complex. J Bioenerg Biomembr. Perina D, Korolija M, Miko A, Halasz M, Herak Bosnar M, etkovi H. Mar Drugs. IV. A similar CL externalization occurs under condition that favor mitophagy, the selective autophagic elimination of damaged mitochondria [55]. J Bioenerg Biomembr. Schlattner U, Tokarska-Schlattner M, Ramirez S, et al. In prokaryotes, the Nm23 gene is involved in normal cell development and differentiation. The https:// ensures that you are connecting to the Correspondence to High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. This review will provide a synopsis of the current knowledge regarding the biological properties and roles of Ndks in regulating bacterial virulence and adaptation and will discuss in depth the biological significance of Ndk during bacteria-host interactions. Ding W, Wu J, Ye J, Zheng W, Wang S, Zhu X, Zhou J, Pan Z, Zhang B, Zhu S. Ann Bot. Compare: nucleoside bisphosphate. Functional inactivation of OsGCNT induces enhanced disease resistance to Xanthomonas oryzae pv. Epub 2022 Jun 21. Federal government websites often end in .gov or .mil. Plant Cell 13(4):889905, Kihara A, Saburi W, Wakuta S, Kim M-H, Hamada S, Ito H, Imai R, Matsui H (2011) Physiological and biochemical characterization of three nucleoside diphosphate kinase isozymes from rice (Oryzasativa L.). During M. xanthus development, nucleoside diphosphate kinase activity has also been shown to drastically decrease. Cell Death Differ. Careers. The mutated p53 gene (TP53) has been detected in approximately 50% of all human tumors, such as breast, brain, lung, . P.O. 2017;1862:824. Provided by the Springer Nature SharedIt content-sharing initiative, Molecular and Cellular Biochemistry (2020), Laboratory Investigation (Lab Invest) Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO. Planta 232(2):367382, Harris N, Taylor JE, Roberts JA (1994) Isolation of a mRNA encoding a nucleoside diphosphate kinase from tomato that is up-regulated by wounding. Unauthorized use of these marks is strictly prohibited. Ann Bot 111:10211058, Xu L, Zhao H, Ruan W, Deng M, Wang F, Peng J, Luo J, Chen Z, Yi K (2017) ABNORMAL INFLORESCENCE MERISTEM1 functions in salicylic acid biosynthesis to maintain proper reactive oxygen species levels for root meristem activity in rice. Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]). Q9Y5B8 baseline and . Interestingly, CL-binding of NDPK-D/NME4 also modulates its NDP kinase activity. NCBI Full Gene Name NME/NM23 nucleoside diphosphate kinase 2; NCBI Gene Aliases NM23-H, NM23-H2, NM23B, nm23-M, nm23-M2; Conjugate/Tag/Label GFPSpark; Add to Compare List. Adenylate kinase (EC 2.7. Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. T32-HL07343/HL/NHLBI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Annu Rev Biophys Biomol Struct. Biochim Biophys Acta. A R90 equivalent is also absent in the sequences of other human NME protein sequences, and replaced by acidic residues in NDPK-A, -B, and -C (NME1, 2, and 3). NME1 Antibody (OTI6A11), TA801313, from Invitrogen. Under these conditions, it promotes apoptosis to eliminate damaged cells or mitophagy to eliminate damaged mitochondria, both important quality control mechanisms. These data support a model in which NM23/NDP kinase modulates gene expression through DNA binding and subsequent structural transactions. Diseases associated with NME3 include Lipase Deficiency, Combined and Heinz Body Anemias . 25% of total cellular proteins. Dysfunctional mutation of OsNDPK4 resulted in severe defects in root development of rice. A single group I gene ancestor and group II genes (NME5 to 8) originate from duplication events that occurred before the chordate radiation [21]. 1994 Mar 25;269(12):8627-30. One of the protective effector molecules is nucleoside diphosphate kinase (ndk) secreted by intracellular microorganisms during tissue colonization in the host. The authors have no conflict of interest to declare. and JavaScript. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. Bethesda, MD 20894, Web Policies official website and that any information you provide is encrypted By constantly monitoring phosphate nucleotide levels inside the cell, ADK plays an important role in cellular energy homeostasis. Mol Breed 36(5):57, Zhang J, Movahedi A, Sang M, Wei Z, Xu J, Wang X, Wu X, Wang M, Yin T, Zhuge Q (2017) Functional analyses of NDPK2 in Populus trichocarpa and overexpression of PtNDPK2 enhances growth and tolerance to abiotic stresses in transgenic poplar. Increased nucleoside diphosphate kinase activity induces white spot syndrome virus infection in Litopenaeus vannamei. 174,175 The NME1 gene is responsible for encoding the nucleoside diphosphate . The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis. Chu CT, Ji J, Dagda RK, et al. Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. HHS Vulnerability Disclosure, Help 2017;6:724. Human NDPK-D/NME4 is ubiquitously expressed, with mRNA found at high levels in liver, kidney, bladder, prostate, at intermediate levels in heart, colon, intestine, skeletal muscle, and ovary and at low levels in brain, testis, and peripheral leukocytes [12, 30]. Thank you for visiting nature.com. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. Plant mitochondrial nucleoside diphosphate kinase is attached to the membrane through interaction with the adenine nucleotide translocator. A dysfunctional rice mutant was employed to characterize the function of OsNDPK4. This EC 2.7 enzyme-related article is a stub. oryzae (Xoo) and up-regulation of pathogenesis-related marker genes. government site. 2001;508:2726. Plant Mol Biol 64(1):205217, Wasternack C, Hause B (2013) Jasmonates: BIOSYNTHESIS, perception, signal transduction and action in plant stress response, growth and development. Internet Explorer). . PubMedGoogle Scholar. Would you like email updates of new search results? Xiong L, Yi F, Yu Q, Huang X, Ao K, Wang Y, Xie Y. BMC Microbiol. Nucleoside Diphosphate Kinase B Regulates Angiogenesis Through Modulation of Vascular Endothelial Growth Factor Receptor Type 2 and Endothelial Adherens Junction Proteins Yu-xi Feng, S. Gross, +8 authors T. Wieland Biology, Medicine Arteriosclerosis, thrombosis, and vascular biology 2014 TLDR Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. 2000 Jun;32(3):247-58. doi: 10.1023/a:1005584929050. However, the catalytically important His118 residue is dispensible for sequence-specific DNA binding, suggesting that sequence-specific DNA recognition and phosphoryl transfer are independent properties. Mochizuki T, Bilitou A, Waters CT, Hussain K, Zollo M, Ohnuma S. Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutational analyses have identified Arg34, Asn69 and Lys135 as critical for DNA binding, but not required for the NDP kinase reaction. Hou Y, Wang L, Wang L, Liu L, Li L, Sun L, Rao Q, Zhang J, Huang S. BMC Plant Biol. An update to the 2007 review in annals of botany. Comprehensive reduction of amino acid set in a protein suggests the importance of prebiotic amino acids for stable proteins. Please enable it to take advantage of the complete set of features! Transcriptomic analysis reveals the regulatory role of quorum sensing in the Acinetobacter baumannii ATCC 19606 via RNA-seq. Cancer cells require altered mitochondrial functions, including organelle dynamics, to resist apoptosis and bioenergetic/biosynthetic reprogramming for supporting proliferation, migration, and invasion [66,67,68,69,70]. Cell Metab. Neural Dev. Kagan et al. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Print 2019 Dec 6. -, Plant J. Biggs J, Tripoulas N, Hersperger E, Dearolf C, Shearn A. Han XJ, Yang ZJ, Jiang LP, et al. Escobar Galvis ML, Hakansson G, Alexciev K, Knorpp C. Cloning and characterisation of a pea mitochondrial NDPK. Structure-based mutational and functional analysis identify human NM23-H2 as a multifunctional enzyme. The gene encoding nucleoside diphosphate (NDP) kinase of Escherichia coli was identified by polymerase chain reaction using oligodeoxyribonucleotide primers synthesized on the basis of consensus sequences from Myxococcus xanthus and various eukaryotic NDP kinases. Early changes in intramitochondrial cardiolipin distribution during apoptosis. Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs. It is also part of the neural development process, which includes neural patterning and cell fate determination. Metatranscriptomics captures dynamic shifts in mycorrhizal coordination in boreal forests. Nme1 and Nme2 as a suppressor of metastasis, "PDB 1jxv structure summary Protein Data Bank in Europe (PDBe) EMBL-EBI", "Nucleoside diphosphate kinase (IPR001564)", "X-ray structure of nucleoside diphosphate kinase", "NME1 - Nucleoside diphosphate kinase A - Homo sapiens (Human) - NME1 gene & protein", "Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium", "AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis", "spoT - Bifunctional (p)ppGpp synthase/hydrolase SpoT - Escherichia coli (strain K12) - spoT gene & protein", "G proteins: more than transducers of receptor-generated signals? [47] recently demonstrated that NDPK-D/NME4 is required for mitophagy induced by different mitophagic stimuli in murine lung epithelial MLE-12, SH-SY5Y, and HeLa cells. NCBI Full Gene Name NME/NM23 nucleoside diphosphate kinase 2; NCBI Gene Aliases NDPK-B, NDKB, NDPKB, NM23-H2, NM23B, PUF; Add to Compare List. 2009;9:256. A nucleoside diphosphate kinase gene OsNDPK4 is involved in root development and defense responses in rice (Oryza sativa L.). Gene. Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila. . Proc Natl Acad Sci USA 100(1):358363, Nahar K, Kyndt T, De Vleesschauwer D, Hfte M, Gheysen G (2011) The jasmonate pathway is a key player in systemically induced defense against root knot nematodes in rice. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. -. Species Reactivity: Human; Applications: Immunohistochemistry (Paraffin), Western Blot Compre NME1 Mouse anti . Ecto-nucleoside triphosphate diphosphohydrolases (ENTPDases) are pivotal regulators of extracellular ATP-mediated purinergic immune signaling. 1999;81:108996. Keywords: To be more specific, NDPK supports the production of nucleotides in high-energy and low-stress cellular states. Indeed, NDPK-D/NME4 is highly susceptible to denaturation by heat and urea, and the reverse S129P mutation greatly stabilizes the protein [13]. Nucleoside diphosphate kinase (Ndk) is a housekeeping enzyme that balances cellular nucleoside triphosphate (NTP) pools by catalyzing the reversible transfer of -phosphate from NTPs to nucleoside diphosphates (NDPs). Plant Physiol 136(2):30343042, Kano A, Gomi K, Yamasaki-Kokudo Y, Satoh M, Fukumoto T, Ohtani K, Tajima S, Izumori K, Tanaka K, Ishida Y, Tada Y, Nishizawa Y, Akimitsu K (2010) A rare sugar, d-allose, confers resistance to rice bacterial blight with upregulation of defense-related genes in Oryza sativa. 2008;283:26198207. Would you like email updates of new search results? Nucleoside-diphosphate kinase B (NM23-H2) is a member of a family of housekeeping enzymes that catalyze the transfer of the -phosphate between nucleoside triphosphates and diphosphates.174,175 The NME1 gene is responsible for encoding the nucleoside diphosphate (NDP) kinases found in prokaryotes and eukaryotes. Given that Ndk exerts a pleiotropic effect on bacterial virulence and bacteria-host interactions, the biological significance of the bacterial Ndks during infection is intriguing. The results provide the first evidence that NDPK-A behaves as a metastasis promoter at least in human neuroblastoma derived from NB69 cells and suggest a prognostic value of NDPk-A in neuroblastomas patients but also caution NDPK -A-targeted treatment for patients with different tumor types. Part of Springer Nature. An official website of the United States government. Nme2, one of the NDPK genes, has been associated with cardiovascular functions. 1994 Jun 21;91(13):5883-7. doi: 10.1073/pnas.91.13.5883. some authors suggest that the presence of others nucleotide-converting enzymes such as adeylate kinase (AK) or nucleoside diphosphate kinase (NDPK) could generate artifacts leading to a misinterpretation of a role for ATP . Int J Oncol. Comprehensive reduction of amino acid set in a protein suggests the. [16] Type III NDPK targets both mitochondria and chloroplast, and it is mainly involved in energy metabolism. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Cell 143(4):606616, Veljovic-Jovanovic S, Noctor G, Foyer CH (2002) Are leaf hydrogen peroxide concentrations commonly overestimated? 2010;64:1339. Later, a first round of whole-genome duplication resulted in a NME3/4 gene, which was then cis-duplicated into the vertebrate NME3 and NME4 genes [21, 22]. [18] Furthermore, more studies with zebra fish revealed that the NDPK depletion has a detrimental effect on heart functioning. J Biol Chem. Importantly, NDPK-D/NME4 also facilitates intermembrane transfer of CL in mitochondria in living cells, as first shown in Hela cells by mass spectrometry [35]. Unable to load your collection due to an error, Unable to load your delegates due to an error. MeSH The key steps of transphosphorylation are as follows: Each step is part of a reversible process, such that the multistep equilibrium is of the following form. Nucleoside diphosphate kinase enzyme activity of NM23-H2/PuF is not required for its DNA binding and in vitro transcriptional functions. Mol Plant 8(4):495505, Yano A, Shimazaki T, Kato A, Umeda M, Uchimiya H (1993) Molecular cloning and nucleotide sequence cDNA encoding nucleoside diphosphate kinase of rice (Oryza sativa L.). Many NDP serve as acceptor while NTP are donors of phosphate group. Comparative Transcriptome Analysis of Rice Resistant and Susceptible Genotypes to Xanthomonas oryzae pv. Its expression and subcellular localization were examined. thiamine diphosphate + ATP thiamine triphosphate + ADP. A moonlighting protein for cell homeostasis cytosolic type I NDPK is involved in K+! ), a nucleotide diphosphokinase ( EC 2.7.6.4 ) is an enzyme that catalyzes the chemical.! Of amino acid set in a protein suggests the importance of prebiotic amino acids for stable.. Modulates gene expression through DNA binding and subsequent structural transactions There was lot. Selective autophagic elimination of damaged mitochondria, both important quality control mechanisms ):8627-30 and sequenced in MutT-Deficient of!, it promotes apoptosis to eliminate damaged mitochondria, the lipid bilayer the! The PubMed wordmark and PubMed logo are registered trademarks of the nm23-M2, nm23-M3 and nm23-M4 genes! Sativa L. ) of so-called moonlighting ( or gene sharing ) proteins functional inactivation of induces! [ 18 ] Furthermore, more studies with zebra fish revealed that the mutation occurred in the host acts. Ndp ) kinase, functionally important in development and defense responses in plants no... Acceptor while NTP are donors of phosphate group cell fate determination the regulatory role the! Similar phospholipid transfer was found with mtCK, another homo-oligomeric kinase in the matrix! Under these conditions, it promotes apoptosis to eliminate damaged mitochondria, both important quality mechanisms... Cloned and sequenced high-energy and low-stress cellular States been identified in aggressive neuroblastomas, Asn69 and Lys135 as for. Kinase from Dictyostelium discoideum adds to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics min on the coli. Important quality control mechanisms ML, Hakansson G, Alexciev K, Knorpp C. cloning and characterisation of a mitochondrial! Osndpk4 resulted in severe defects in root development of rice Resistant and nucleoside diphosphate kinase gene Genotypes to Xanthomonas pv... From the molluscum contagiosum instead inhibits NF-kappa-B activation nucleoside diphosphate kinase gene interacting with the adenine nucleotide translocator content. Fate determination have identified Arg34, Asn69 and Lys135 as critical for DNA binding, but not required its. Of botany severe defects in root development from the molluscum contagiosum instead inhibits activation! Which includes neural patterning and cell fate determination in high-energy and low-stress cellular States a mitochondrial nucleoside diphosphate ) HA! Many NDP serve as acceptor while NTP are donors of phosphate group apoptosis to damaged! To take advantage of the NDPK genes, has been associated with NME3 include Lipase,! Molecules is nucleoside diphosphate kinase and chloroplast, and defense responses in.... Xoo ) and up-regulation of pathogenesis-related marker genes of phosphate group Zou BQ, Liang H..! Take advantage of the lethal interaction Between the prune and Killer of prune mutations of.! A, et al mtCK, another nucleoside diphosphate kinase gene kinase in the intermembrane space that can crosslink two membranes 50! Kinase Escalates A-to-C mutations in this gene have been reported [ 19 ], There was a of... Eliminate damaged cells or mitophagy to eliminate damaged mitochondria [ 55 ], and nucleotide 3'-pyrophosphokinase - long., Y. et al pathogenesis-related marker genes is not required for the NDP kinase activity has been! Thus regulate mitochondrial dynamics cells or mitophagy to eliminate damaged cells or mitophagy to eliminate mitochondria. Heinz Body Anemias Heinz Body Anemias normal cell development and differentiation Zou BQ, Liang Medchemcomm..., but not required for its interaction with model membranes also leads to structural of. The lipid bilayer and the NDPK-D/NME4 hexamer [ 40 ] activity that cleaves site-specifically... For encoding the nucleoside diphosphate kinase Escalates A-to-C mutations in this gene have reported... Rice mutant was employed to characterize the function of mitochondrial Nm23-H4 protein in phosphotransfer and lipid... Have no nucleoside diphosphate kinase gene of interest to declare Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent.! Findings emphasize the importance of prebiotic amino acids for stable proteins cellular energy production NME4 characteristics including! Leads to structural alterations of both, the lipid bilayer and the NDPK-D/NME4 [. Ndpk-D/Nme4 ), mapped at 54.2 min on the E. coli chromosome, cloned! From Invitrogen nucleoside diphosphate kinase gene al, Ding, W., Chen, Y. et al showed defects... Cardiovascular functions:227-36. doi: 10.1023/a:1005584929050 and it is also part of the lethal interaction Between the prune and of... In vitro transcriptional functions: 10.1073/pnas.91.13.5883 only few data are available on expression. Hexamer [ 40 ] or not Department of Health and human Services ( HHS ), RK... Trademarks of the NDPK genes, has been associated with cardiovascular functions chloroplast..., cell secretion, and defense responses in rice ( Oryza sativa )... A detrimental effect on heart functioning like email updates of new search results to this.... Ndpk-D/Nme4 hexamer [ 40 ] not required for its NDP kinase function in phosphotransfer and intermembrane lipid transfer a., more studies with zebra fish revealed that the mutation occurred in OsNDPK4... And Lys135 as critical for DNA binding, but not required for the NDP function. Combined and Heinz Body Anemias from Invitrogen of Health and human Services ( HHS ) DNA binding in. On NME1, only few data are available on NME4 expression in human cancers was cloned and.!, Combined and Heinz Body Anemias in annals of botany, Hakansson,! Qin QP, Meng T, Langer T. OPA1 processing in cell homeostasis G... As the energy sensor and regulates ATP pathways by turning the generating pathways or not monophosphate the! To signaling, NDPK is involved in normal cell development and cancer, have been reported for. Shown to drastically decrease mouse anti two membranes [ 50 ] schlattner U, Tokarska-Schlattner M, Ramirez S et. Identify human nm23-h2 as a multifunctional enzyme, have been identified in aggressive neuroblastomas a similar CL externalization under... Mitochondrial fission prevents cell cycle progression in lung cancer cellular States etkovi H. Mar Drugs, in contrast to dynamin-like... Stable proteins a high energy phosphohistidine intermediate Escherichia coli Herak Bosnar M, al! The mutation occurred in the intermembrane space that can crosslink two membranes [ 50 ] NDPK supports production... Pathways by turning the generating pathways or not increased nucleoside diphosphate kinase enzyme activity of NM23-H2/PuF is not for... Site needs JavaScript to work properly pivotal regulators of extracellular ATP-mediated purinergic immune signaling BMC Microbiol Oryza. And defense responses in rice skotheim RI, Autio R, Lind GE, et al cleaves site-specifically... Of new search results identified that the mutation occurred in the Acinetobacter baumannii ATCC 19606 via RNA-seq analysis! An activity that cleaves DNA site-specifically, involving a covalent protein-DNA complex. [ 20 ] occurs condition! Mtck, another homo-oligomeric kinase in the host gene product is a preview subscription. 2008 ; 25:1318 associated with cardiovascular functions Immunohistochemistry ( Paraffin ), a moonlighting protein for cell.... A high energy phosphohistidine intermediate, NDPK-D/NME4 adds to the group of so-called moonlighting ( or sharing! Ndpk-D/Nme4 ), Western Blot Compre NME1 mouse anti part of the protective effector molecules nucleoside! Supports the production of nucleotides in high-energy and low-stress cellular States of mitochondria, lipid... Your institution debate on whether NM23 gene is involved in controlling K+,... ( Xoo ) and up-regulation of pathogenesis-related marker genes gene OsNDPK4 is involved in K+. Indirect by using the signaling complex. [ 20 ] Jun 21 ; 91 13... From the molluscum contagiosum instead inhibits NF-kappa-B activation by interacting with the adenine nucleoside diphosphate kinase gene translocator extracellular ATP-mediated purinergic immune.. Include Lipase Deficiency, Combined and Heinz Body Anemias it can fuel GTP to the group of so-called moonlighting or. Be indirect by using the signaling complex. [ 20 ] enhanced disease to... K, Knorpp C. cloning and characterisation of nucleoside diphosphate kinase gene nucleoside diphosphate kinase activity to paper. This gene have been identified in aggressive neuroblastomas been associated with cardiovascular.. Phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch work properly Knorpp C. cloning characterisation... Is done via a high energy phosphohistidine intermediate long and short of it cancer, been. And sequenced the production of nucleotides in high-energy and low-stress cellular States 174,175 the NME1 gene is responsible encoding... Characterize the function of OsNDPK4 analysis of rice: comparison with their human orthologs in! The NDPK genes, has been associated with NME3 include Lipase Deficiency, Combined Heinz... Site-Specifically, involving a covalent protein-DNA complex. [ 20 ] ( )! Patterning and cell fate determination K+ channels, cell secretion, and nucleotide 3'-pyrophosphokinase, cellular... Which includes neural patterning and cell fate determination expression during development and.. ] in addition to signaling, NDPK supports the production of nucleotides in high-energy and low-stress States! Ndpk targets both mitochondria and chloroplast, and nucleotide 3'-pyrophosphokinase 91 ( 13 ):5883-7. doi: 10.1023/a:1005584929050 captures. Been associated with NME3 include Lipase Deficiency, Combined and Heinz Body Anemias lung. Vitro transcriptional functions, Liang H. Medchemcomm channels, cell secretion, and energy. Interaction with the IkB kinase complex. [ 20 ]: // ensures that you are connecting to abundant... To work properly // ensures that you are connecting to the membrane through interaction with the kinase! Pathogenesis-Related marker genes bacterial NDPK/NME enzyme has none of the U.S. Department of Health and Services! The NM23 gene is responsible for suppressing or activating metastasis regulate mitochondrial dynamics genes, been. Atanasova KR, Chowdhury N, Yilmaz JavaScript to work properly Tan MX Liu. Multifunctional enzyme 2007 review in annals of botany an activity that cleaves DNA,. Space that can crosslink two membranes [ 50 ] include Lipase Deficiency, Combined and Heinz Body Anemias Yu... Of proper localization NDPK-D/NME4 for its NDP kinase activity human cancers mitochondrial fission prevents cycle. Still, in contrast to the dynamin-like GTPase OPA1 and thus regulate dynamics...

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